Alcohol or drug abuse: You may be at an increased risk for liver damage or dependence.
Allergic reaction to any barbiturate, acetaminophen, or caffeine: Do not take Fioricet.
Asthma: Increased risk of serious side effects
Depression: Butalbital may worsen this condition
Diabetes (sugar): Butalbital may worsen this condition
Heart disease: Caffeine may make certain heart conditions worse
Hepatitis or other liver damage: Increased risk of serious side effects
Hyperactivity (children): Increased risk of serious side effects
Kidney disease: Increased risk of serious side effects
Overactive thyroid: Butalbital may worsen this condition
Porphyria: Butalbital is listed as an unsafe drug for porphyria, an enzyme deficiency that can cause fragile skin that is sensitive to sunlight, digestive difficulties, anxiety, and reddish-brown urine.